Intranasal instillation of rats with a suspension of 5 x 10(6) Klebsiella pneumoniae caused bronchopneumonia with 24 h. It has been a known human pathogen since it was first isolated in the late nineteenth century by Edwin Klebs. Introduction . Klebsiella pneumoniae is a member of the Klebsiella genus of Enterobacteriaceae and belongs to the normal flora of the human mouth and intestine. Molecular pathogenesis of Klebsiella pneumoniae. The following model was developed to study the pathogenesis and evaluate therapy of such infections. INTRODUCTION. Li B(1), Zhao Y, Liu C, Chen Z, Zhou D. Author information: (1)Department of Dermatology, Taihe Hospital, Hubei University of Medicine, Shiyan, Hubei, China. Klebsiella pneumoniae is a gram-negative, lactose-fermenting, non-motile, aerobic rod-shaped bacterium. Klebsiella pneumoniae was first described by a German microbiologist and pathologist Carl Friedländer in 1882. Gram-negative bacterial pneumonias have been increasingly important as nosocomial infections. K. pneumoniae is found in the normal flora of skin, mouth and intestines, where it does not cause disease. Of the pathogenic Klebsiella species, K. pneumoniae is the most prevalent and clinically important. Klebsiella pneumoniae is a gram-negative, encapsulated, non-motile bacterium that is found in the environment and has been associated with pneumonia in the alcoholic and diabetic patient population. Klebsiella pneumoniae- Pathogenicity and Clinical Manifestations. K. pneumoniae is also a well-known cause of community-acquired pneumonia. INTRODUCTION. by Wenlie Xie and Huixuan Jia. Klebsiella pneumonia is often found as part of the normal flora in the upper and lower gastrointestinal tracts of many nonhuman primates. Pathogenesis. Infections with K. pneumoniae are usually hospital-acquired and occur primarily in patients with impaired host defenses. Pathogenic strains associated with the upper respiratory tract are usually heavily encapsulated.

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